We found the turquoise light to be 20% more efficient than the blue light ( 7). blue fluorescent light with peak emission at 490 and 452 nm, respectively, with equal spectral irradiance on preterm infants. Therefore, we previously compared the bilirubin-reducing effect of turquoise vs. ( 6) predicted that the greatest effect of phototherapy would be in the spectral range 495 ± 10 nm. Based on a skin optical model, Agati et al. This practice is, among others, based on the results of Cremer et al.’s original clinical study ( 3) and of in vitro experiments ( 4, 5). The decrease in total serum bilirubin (TSB) is the result of light absorption by bilirubin in the skin which transforms the native toxic, nonpolar Z,Z-bilirubin into more excretable polar photoisomers: the configurational isomers Z,E- and E,Z-bilirubin and the structural isomers Z- and E-lumirubin ( 1).īlue light with an emission peak of about 460 nm, matching the absorption spectrum of a bilirubin–albumin solution in vitro, is routine treatment for hyperbilirubinemia worldwide as it is considered to be the most effective ( 2). Deposition of unconjugated bilirubin in the central nervous system may cause serious neurodevelopmental impairment (kernicterus).ĭue to its efficacy and safety, phototherapy is the treatment of choice for jaundice. In rare infants, the condition progresses into acute bilirubin encephalopathy. Jaundice occurs in the majority of term neonates during the first week of life and is generally harmless. Using LED light of equal irradiance, turquoise and blue lights had equal bilirubin-reducing effect on hyperbilirubinemia of neonates. The decrease was positively correlated to postnatal age and negatively to birth weight. The difference was nonsignificant ( P = 0.53). The median (95% confidence interval) decrease of total serum bilirubin was 35.3% (32.5 37.3) and 33.1% (27.1 36.8) for infants treated with turquoise and blue lights, respectively. Results:įorty-six infants received turquoise light and 45 received blue light. The mean irradiance footprint at skin level was 5.2 × 10 15 and 5.1 × 10 15 photons/cm 2/s, respectively. Infants with gestational age ≥33 wk and uncomplicated hyperbilirubinemia were randomized to either turquoise or blue LED light and were treated for 24 h. Hence, the aim of this study was to compare the bilirubin-reducing effect in jaundiced neonates treated either with turquoise or with blue LED light with peak emission at 497 or 459 nm, respectively, with equal irradiance on the infants. At present, the predominant light source for phototherapy is light emitting diodes (LEDs). However, studies using fluorescent light tubes have suggested that turquoise light with peak emission at 490 nm may be more efficient. Blue light with peak emission around 460 nm is the preferred treatment of neonatal hyperbilirubinemia.
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